Machine learning algorithm rapidly reconstructs 3D images from X-ray data

Soon, researchers may be able to create movies of their favorite protein or virus better and faster than ever before. Researchers at the Department of Energy’s SLAC National Accelerator Laboratory have pioneered a new machine learning method—called X-RAI (X-Ray single particle imaging with Amortized Inference)—that can “look” at millions of X-ray laser-generated images and create a three-dimensional reconstruction of the target particle. The team recently reported their findings in Nature Communications.