Single-cell genomics technologies enable multimodal profiling of millions of cells across temporal and spatial dimensions. Experimental limitations prevent the measurement of all-encompassing cellular states in their native temporal dynamics or spatial tissue niche. Optimal transport theory has emerged as a powerful tool to overcome such constraints, enabling the recovery of the original cellular context. However, most algorithmic implementations currently available have not kept up the pace with increasing dataset complexity, so that current methods are unable to incorporate multimodal…
Multimodal large language models (MLLMs) have recently shown strong performance in visual understanding, yet they often lack temporal awareness, particularly in egocentric settings where reasoning depends on the correct ordering and evolution of events. This deficiency stems in part from training objectives that fail to explicitly reward temporal reasoning and…
The rapid progress of foundation models and large language models (LLMs) has fueled significantly improvement in the capabilities of machine learning systems that benefit from mutlimodal input data. However, existing multimodal models are predominantly built on top of pre-trained LLMs, which can limit accurate modeling of temporal dependencies across other…